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MCT1-dependent mitochondrial lactate import sustains cardiac metabolism
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11182-3In mouse myocardium, glucose oxidation persists in the absence of the mitochondrial pyruvate carrier, with mitochondrial MCT1 importing lactate …
Tumour assembloids recapitulate tumour–CAF–T cell crosstalk in renal cancer
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11208-wTumour assembloids, which model components of human renal cell carcinoma, including cancer cells, cancer-associated fibroblasts and tumour-infiltrating immune cells, …
Emotion regulation capacity lacks a shared neural signature
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11203-1Sensorimotor and amygdala activation, but not canonical prefrontal control circuits, indicate emotion regulation capacity.
Rare and common genetic variants shape single-cell immune gene expression
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-10721-2Phase 1 of TenK10K takes single-cell RNA sequencing and matched whole-genome sequencing data from 1,925 individuals, enabling detection of …
T and B cells recognize splicing-derived neutrophil neoantigens in lupus
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11219-7In systemic lupus erythematosus, aberrant splicing in neutrophils generates novel peptides that are presented on MHC I, driving CD4+ …
Diet at disease onset determines tissue inflammatory memory
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11181-4Dietary state during a narrow temporal window can durably reprogram disease trajectory.
Subcycle videography of Landau–Zener–Majorana transitions in graphene
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11214-yAn experimental concept enabling attosecond-precision, subcycle band-structure videography covering the entire first Brillouin zone is demonstrated and used to …
Molecular underpinnings of rheumatic diseases and emerging therapeutic concepts
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-10966-xImproved molecular insights into inflammatory rheumatic diseases are enabling better disease control and advancing the field towards achieving durable …
Narrow carbon pentaheptite nanoribbon as a covalent metal
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11202-2Planar carbon pentaheptite nanoribbons are synthesized by laterally fusing polypentalene chains transformed from pre-synthesized polycyclooctadiene chains, suggesting a possible …
Connectome simulations identify a central pattern generator for fly walking
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11195-yComputational simulations of a neural network based on fly connectomes identify a three-neuron circuit that is organized to produce …
Perinatal elimination of genetically aberrant human cortical neurons
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11190-3Single-neuron sequencing shows that widespread genomic abnormalities are common prenatally but largely eliminated around birth, indicating developmental genome quality …
Delayed electron–hole recombination in a pseudo-direct semiconductor
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11223-xPseudo-direct bandgap character in bismuth sulfide retards bimolecular electron–hole recombination while preserving strong light absorption.
Tandem repeat variation shapes immune cell type-specific gene expression
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-10438-2Whole-genome sequencing and cell-level gene expression measurements show that length variation in tandem repeats in the human genome contributes …
<i>Clostridium perfringens</i> Delta toxin targets CD9 to drive NEC and brain injury
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11211-1A subset of necrotizing enterocolitis in infants is mediated specifically by the Clostridium perfringens Delta toxin.
Stone and water governed early human settlement of the desert
Nature, Published online: 28 October 2026; doi:10.1038/s41586-026-11180-5A geoarchaeological survey of the Rub’ al Khali (the Empty Quarter of Arabia) and spatial modelling of the Arabian …
The shifting sands of research independence: why mid-career scientists crave security
Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-02670-7A project to improve understanding of an often-neglected group in academia aims to help its members to navigate career …
Where have all the saucers flown?
Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-03107-xMissed encounters.
Ribbon made of carbon pentagons and heptagons has metallic properties
Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-03298-3Ribbons that are composed exclusively of five- and seven-carbon rings have metal-like electron transport and conductance. The ribbons can …
Daily briefing: The big push to personalize psychiatry
Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-03531-zA data-driven approach could match treatments to individuals with more precision. Plus, funders in Europe are backing preprint-led publishing …
Genetic variants that alter gene regulation in specific cell types are closely …
Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-03067-2Single-cell profiling of nearly 2,000 people brings scientists closer to understanding the link between genetic variation, gene expression and …
How the pandemic changed trust in science — in four charts
Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-03248-zThe largest analysis of its kind reveals the public’s changing relationship with science and the people who do it.
Meta-study sparks questions about what it means to be good at regulating …
Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-03262-1A first-of-its kind consortium reveals a lack of correlation between behavioural and neural measures of a person’s emotional regulation.
An unexpected function of a cell-cycle enzyme might explain the toxic effects …
Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-03288-5A previously unknown mechanism required for cells to start proliferating has been identified. A combination of mathematical modelling and …
Could a giant sunshade in space ‘solve global warming’? Scientists are taking …
Nature, Published online: 28 October 2026; doi:10.1038/d41586-026-03415-2Some say the concept is complete fantasy, but a detailed analysis suggests that the falling cost of rocket launches …
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