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Mechanism of age-related accumulation of mtDNA mutations in human blood
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10569-6Genome-wide analyses indicate that accumulation of mitochondrial DNA mutations, a hallmark of ageing, may be caused by cryptic replication …
Redesigning algorithms to intervene on social norm misperceptions during a national election
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10536-1Engagement-based feeds amplify intergroup, moralized, emotional (IME) and toxic content relative to reverse-chronological feeds, and a diversified extremity algorithm …
Experimental randomness amplification
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10521-8An experimental realization of device-independent randomness amplification is demonstrated using superconducting qubits, in which a source of weak, correlated …
Cavity-driven attractive interactions in quantum materials
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10609-1A broadband, sub-wavelength time-domain microscope is described, enabling the observation that terahertz light trapped within a cavity can mediate …
Dynamical freezing for magnetometry in an interacting spin ensemble
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10585-6Dynamical freezing, a mechanism by which a driven quantum system may not thermalize to a featureless ‘infinite-temperature’ state at …
Spatiotemporal transcriptome atlas of human embryos after gastrulation
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10545-0A spatiotemporal transcriptome atlas of whole-human embryos after gastrulation and previously transcriptionally undescribed stages of human development are reported.
Transcription factor codes patterning neuronal groundplans of the cerebrum
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10526-3Researchers mapped how transcription factors define neuron lineages in fruit fly brains, revealing hierarchical genetic programs that shape and …
Substrate selectivity of the human RNA m<sup>5</sup>C methyltransferase NSUN2
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10582-9NSUN2 is an enzyme that adds a small chemical mark to RNA molecules and uniquely selects its targets based …
Universal transcriptomic hallmarks of mammalian ageing and mortality
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10542-3Integration of gene expression data from multiple tissues across four mammalian species reveals conserved transcriptomic signatures of mammalian ageing …
Distinct genetic architecture in the tails of complex traits
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10516-5Genome-wide analyses in multiancestry and European cohorts show that in complex traits, rare alleles have disproportionately large effects at …
Cellular water-potential sensing through biomolecular condensation
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10591-8Plants sense water deficiency through SAM8 protein condensation, which responds to reduced hydration and triggers stress adaptation by altering …
Four ppm measurement of the antihydrogen ground-state hyperfine splitting
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10556-xA measurement of the hyperfine splitting energy of the ground state of antihydrogen at 4 ppm precision reaches a …
αKG-mediated carnitine synthesis drives DNA repair via histone acetylation
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10584-7The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has …
Technology mediation in child sexual exploitation and abuse in Africa and Asia
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10525-4Enabling parental mediation of online activities and children’s knowledge of where to seek help after sexual harassment or assault …
Sparse-to-dense coding transformation between hippocampal areas CA3 and CA1
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10537-0The hippocampus exhibits a CA3-to-CA1 coding transformation that combines fast learning with an efficient, compressed neural code.
Darkness and body size shaped end-Cretaceous marine extinction patterns
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10541-4Trait-based ecosystem modelling shows that impact-driven darkness and body-size-dependent extinction thresholds, rather than carbon-dioxide increase or acidification, drove most …
Human haematopoietic stem cells remember inflammatory stress
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10522-7Using xenograft inflammation–recovery models and single-cell multiomics, a haematopoietic stem cell population after inflammatory stress is identified.
β-Arrestin condensates regulate G-protein-coupled receptor function
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10539-yβ-Arrestins, multifunctional adaptor proteins that regulate G-protein-coupled receptors (GPCRs), form phase-separated condensates, suggesting that β-arrestin liquid–liquid phase separation organizes …
Bohmian mechanics remains unchallenged by tunnelling experiment
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10450-6Bohmian mechanics remains unchallenged by tunnelling experiment
Author Correction: Satellite megaconstellations will threaten space-based astronomy
Nature, Published online: 27 May 2026; doi:10.1038/s41586-026-10553-0Author Correction: Satellite megaconstellations will threaten space-based astronomy
Nests in an egg cell: structures of protein-storage units in oocytes
Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01414-xA fertilized egg’s first few divisions rely on proteins stored in fibrous structures. The ordered nature of these structures …
Global lung cancer burden shifting to middle-income countries
Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01461-4High smoking rates and polluted air mean lung cancer cases are rising fastest in places such as China. Africa …
Lung cancer in women emerges as a distinct disease
Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01459-yA malignancy that once mainly affected men has broadened its reach. But marked disparities in research, detection and treatment …
Could a pill prevent the world’s deadliest cancer?
Nature, Published online: 27 May 2026; doi:10.1038/d41586-026-01382-2‘Interception’ drug trials hope to stop lung cancer before it starts.
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