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Latest news from trusted sources around the world
Algorithm that gets ‘under the hood’ of AI models could effectively steer …
Nature, Published online: 29 April 2026; doi:10.1038/d41586-026-01267-4A method for identifying representations of concepts in neural networks could provide a more-effective way to control and monitor …
A cell atlas charts the immune architecture of diabetic kidney disease
Nature, Published online: 29 April 2026; doi:10.1038/d41586-026-01177-5Single-cell gene-expression profiling and spatial mapping have revealed the immune microenvironments comprising aggregated immune cells called B cells in …
In the flesh
Nature, Published online: 29 April 2026; doi:10.1038/d41586-026-01073-yCyberspace can’t fulfil every need.
Friendlier LLMs tell users what they want to hear — even when …
Nature, Published online: 29 April 2026; doi:10.1038/d41586-026-01153-zA large language model that is trained to respond in a warm manner is more likely to give incorrect …
Daily briefing: Octopuses’ strange brains might teach us what intelligence really is
Nature, Published online: 29 April 2026; doi:10.1038/d41586-026-01431-wCephalopods are very smart, but have brains that evolved very differently than vertebrates. Plus, detailed maps of olfactory receptors …
Delivering an immune therapy into tumours instead of intravenously reduces adverse effects
Nature, Published online: 29 April 2026; doi:10.1038/d41586-026-01193-5In people with advanced skin cancer, injecting low doses of an anticancer immunotherapy directly into tumours, rather than administering …
Higher racial diversity in US business and law schools is linked to …
Nature, Published online: 29 April 2026; doi:10.1038/d41586-026-01273-6Two comprehensive data sets concerning students who graduated from 141 business schools over 29 years and 200 law schools …
Cephalopods deserve higher welfare standards in research
Nature, Published online: 29 April 2026; doi:10.1038/d41586-026-01320-2These highly sentient creatures have weak protections for their well-being. That must change.
Competition between separated parental genomes in fertilized eggs aids development
Nature, Published online: 29 April 2026; doi:10.1038/d41586-026-01270-9In fertilized egg cells, the maternal and paternal genomes are enclosed in separate compartments called pronuclei. Experiments in mice …
Why you should ‘feed a cold’: eating primes immune cells for action
Nature, Published online: 29 April 2026; doi:10.1038/d41586-026-01362-6Infection-fighting T cells from people who have eaten recently can proliferate more quickly in response to threats.
Engineered blood clots stop bleeding in seconds
Nature, Published online: 29 April 2026; doi:10.1038/d41586-026-01150-2Red blood cells have been modified to form strong clots that halt any bleeding almost instantly and then promote …
Submicrometre sampling of living cells by macrophages
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10435-5Macrophages can sample antigens from living cells through a trogocytosis-like mechanism that routes ingested material away from degradation, a …
Evolutionary characterization of lung cancer metastasis
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10428-4DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme …
Intrinsic polar vortex crystals in A-site layer-ordered perovskites
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10470-2A two-dimensional polar hedgehog lattice spontaneously forms in layer-ordered perovskites, showing stable topological ferroelectric states without external constraints and …
Postprandial lipid metabolism durably enhances T cell immunity
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10432-8Experiments in mice and humans show enhancement of T cell function following fasting and refeeding, caused by persistent immunometabolic …
Racial diversity in higher education is associated with higher student salaries
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10425-7A longitudinal study shows that racial diversity in higher education is associated with higher student salaries at graduation, indicating …
Demography and life histories across the Roman frontier in Germany 400–700 <span>ce</span>
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10437-3Analysis of 258 ancient genomes from southern Germany reveals a major demographic shift during the late fifth century, yet …
Pervasive and programmed nucleosome distortion on single chromatin fibres
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10418-6An analytical pipeline called Iteratively Defined Lengths of Inaccessibility (IDLI) maps the genome-wide occupancy of a range of nucleosome …
Prime assembly with linear DNA donors enables large genomic insertions
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10460-4Prime assembly can initiate Gibson-like assembly in cells to generate gene insertions without double-stranded DNA breaks, recombinases or homology-directed …
Charge-dependent spectral softenings of primary cosmic rays below the knee
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10472-0The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with …
Higher-order interactions enhance the latitudinal tree diversity gradient
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10434-6Higher-order interactions are shown to contribute to the decrease in species diversity from low to high latitudes in global …
Uncertain dynamic response of mid-latitude winter precipitation
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10474-ySeparating the anthropogenic forced thermodynamic and dynamic components from internal variability in winter precipitation trends in the mid-latitudes shows …
The past, present and future of de novo protein design
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10328-7A Review of de novo protein design highlights key methodological advances and achievements, current challenges and future applications.
GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10427-5GLP-1–GIP–lanifibranor, a single-molecule agonist of GLP-1R, GIPR, PPARα, PPARγ and PPARδ, shows promising therapeutic efficacy against obesity-linked metabolic dysfunction …
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