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Genetics reveal why people respond differently to GLP-1 weight-loss drugs

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-00905-1Genetic variants in GLP1R and GIPR, which encode targets of GLP-1-based medications, offer insights into why responses to these …

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Hidden human–virus interactions uncovered in DNA in blood and saliva

Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-01032-7The abundance of viral DNA was measured in DNA sequenced from blood and saliva samples in biobanks, revealing strong …

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Synthetic super-enhancers enable precision viral immunotherapy

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10329-6Synthetic super-enhancers enable specific delivery of anticancer payloads, achieving tumour elimination after a single dose in a mouse model …

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Superconductivity and electronic structures of nickelate thin film superstructures

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10352-7Engineered Ruddlesden–Popper nickelate superstructures show that specific Fermi surface features enable ambient-pressure superconductivity, linking structural configuration, electronic structure and …

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Satellite imagery reveals increasing volatility in human night-time activity

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10260-wDaily satellite data reveal that Earth’s artificial lights at night are highly volatile, with frequent brightening and dimming between …

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Population-scale repeat expansions elucidate disease risk and brain atrophy

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10345-6Decreased brain volumes and increased NfL levels can be observed earlier than disease diagnosis in short-tandem-repeat-associated neurological diseases.

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Multiomics and deep learning dissect regulatory syntax in human development

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10326-9The Human Development Multiomic Atlas catalogues single-cell accessibility and gene expression data from human fetal cells across 12 organs, …

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Metabolomics across scales: from single cells to population studies

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10277-1This Perspective reviews the potential and the challenges of metabolomics approaches, encompassing both single-cell and population-scale metabolomics.

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Asymmetric selection of a rice immune module and rebuild of disease resistance

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10361-6Stacking XA48-mediated effector-triggered immunity with XA21-mediated pattern-triggered immunity in Oryza sativa japonica reconstitutes the broad-spectrum resistance from wild rice.

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Clinical application of base editing for treating β-thalassaemia

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10342-9A clinical phase 1 trial of a single infusion of CS-101, CD34+ cells modified using a transformer base editor …

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Mummified early Permian reptile reveals ancient amniote breathing apparatus

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10307-yA mummified fossil of the early Permian reptile Captorhinus reveals the potential ancestral amniote breathing mechanism and its impact …

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Genetic predictors of GLP1 receptor agonist weight loss and side effects

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10330-zIdentification of genetic variants associated with the efficacy and side effects of GLP1 medications could underpin development of precision …

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High-precision measurement of the W boson mass with the CMS experiment

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10168-5The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in …

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Single-cell spatiotemporal dissection of the human maternal–fetal interface

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10316-xA single-cell multiomic atlas of the human maternal–fetal interface across pregnancy reveals cell types, states and spatial niches, developmental …

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High-fidelity collisional quantum gates with fermionic atoms

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10356-3A robust composite pair-exchange gate based on controlled interactions of fermionic atoms in an optical superlattice demonstrates high fidelities …

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DNA damage drives antigen diversification in <i>Trypanosoma brucei</i>

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10337-6An in vitro toolkit for studying VSG diversification defines key molecular requirements underlying the formation of mosaic VSGs, providing …

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The importance of competition and facilitation for global tree diversity

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10349-2Across 17 forest plots (2.7 million trees, 5,400 species), competition dominated overall, but facilitation was relatively stronger near the …

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Saturation editing of <i>RNU4-2</i> reveals distinct dominant and recessive disorders

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10334-9Saturation genome editing of RNU4-2 identifies the functional and clinical impact of variants across the entire gene and delineates …

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Author Correction: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10488-6Author Correction: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

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Author Correction: Foundation model of neural activity predicts response to new stimulus …

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10457-zAuthor Correction: Foundation model of neural activity predicts response to new stimulus types

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Protected quantum gates using qubit doublons in dynamical optical lattices

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10285-1A purely geometric two-qubit SWAP gate can be realized by transiently populating qubit doublon states of fermionic atoms in …

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Biodiversity resilience in a tropical rainforest

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10365-2Assessment of how 16 taxonomic groups in a lowland tropical forest resist and recover from anthropogenic disturbance shows the …

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Engineered immunosuppressive dendritic cells protect against cardiac remodelling

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10346-5Lesion-targeted immune modulation is a feasible strategy to control cardiac fibrosis, and engineered dendritic cells are a promising therapeutic …

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High-precision calculation of the quark–gluon coupling from lattice QCD

Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10339-4Large-scale lattice quantum chromodynamics simulations enable a model-free, highly precise determination of the strong coupling constant αs, reducing theoretical …

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