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A Jurassic mammaliaform swimmer and transformation of the mammalian pharynx
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11107-0A swimming and water-foraging mammaliaform, Megacauda sungei gen. et sp. nov., had a lifestyle analogous to the extant platypus, …
Cryo-EM structure of a methanogen nitrogenase–PII protein supercomplex
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11116-zCryo-electron microscopy of a nitrogenase supercomplex from a methane-producing archaeon reveals a mechanism in which PII proteins drive assembly …
A split attractor design for rapidly writing a navigational goal
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11144-9The recurrent h∆K–PFG neural circuit generates persistent heading memories through slow excitation, fast inhibition and a disinhibitory gate, where …
Spatially deterministic nucleation of 2D semiconductors by etching flux
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11095-1Etching-flux-mediated single-centred nucleation of two-dimensional semiconductors is used to deterministically localize a single nucleation event, expanding semiconductor deposition from …
Retrofitting language models to operate over bytes
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11111-4Byteification is a general method for retrofitting large language models to operate over bytes such that they approach the …
Australia’s current wildfire crisis linked to colonial land-use change
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11097-zA 1,000-year lake-sediment record from southeastern Australia shows that colonial disruption of Indigenous cultural burning transformed open woodland into …
Dynamics of human cardiogenesis and its disruption in trisomy 21
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11125-ySingle-cell and spatial multiomics are combined to define niches in the developing human heart, revealing pacemaker-cell organization, cardiomyocyte maturation …
A chiral superlattice route to spin-split topological antiferromagnetism
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11073-7A chiral superlattice in collinear antiferromagnetic UOTe generates large Berry curvature and spin-polarized currents, enabling anomalous Hall effects and …
tRNA dosage regulates lineage dependency and resistance in prostate cancer
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11153-8A tRNA-specific regulatory pathway is associated with codon biology, lineage transitions and therapy resistance in prostate cancer.
Overcoming key challenges in the evolutionary transition to multicellularity
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11038-wThis Review synthesizes an evolutionary framework for understanding the key stages, challenges and microevolutionary processes through which single cells …
A 7-eV bandgap semiconductor based on silicon-doped α-(Al<sub><i>x</i></sub>Ga<sub>1−<i>x</i></sub>)<sub>2</sub>O<sub>3</sub>
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11085-3Suboxide molecular-beam epitaxy is used to grow silicon-doped α-(AlxGa1−x)2O3 films with bandgaps exceeding 7.0 eV, enabling the fabrication of …
Mechanism of spliceosome termination
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11101-6A coordinated sequence of RNA helicases and associated factors dismantles normal and defective spliceosome complexes to enable intron degradation …
A preinvasive regulatory T cell axis for lung cancer interception
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11066-6An effector regulatory T cell circuit is identified that can be monitored in blood samples to track the development …
Prehistoric global migration of vanishing gut microbes with humans
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11106-1Microbial species disappearing from industrialized populations have evolved with humans over millennia and migrated worldwide with them—this may have …
Experimental observation of critical topology
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11099-xExperimental evidence indicating that critical gapless topological states can be characterized by the entanglement spectrum and wavefunctions is presented, …
Alveolar stem cells transdifferentiate to drive bronchiolar regeneration
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11127-wIdentification of a cross-compartmental cellular mechanism for bronchiolar epithelial repair informs therapeutic strategies for airway injury.
Hydrogen bonding in water under extreme confinement
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-10858-0A new technique allows direct nanoscale observations of the vibrational response of water confined inside carbon nanotubes, revealing that …
A nuclear clock synchronized to <sup>229</sup>Th
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11122-1A nuclear clock synchronized to 229Th establishes laser-addressed nuclei as operational clock references and 229Th:CaF2 as a stable, reproducible …
Structural basis for regulating lipopolysaccharide transmembrane transport
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11129-8Structures of the protein machinery in Gram-negative bacteria that transports lipopolysaccharide (LPS) from the cytoplasmic membrane to the outer …
A thorium-229 optical nuclear clock with feedback loop
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11084-4A thorium-229 nuclear clock is realized by stabilizing a continuous-wave laser to the 148-nm nuclear excitation with a rapid …
RNA catalysis emerges from dynamic structural ensembles
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11140-zRNase P RNA forms shifting active and inactive conformers whose catalytic activity depends on Mg2+-driven tertiary-interaction dynamics, which are …
Observation of relativistic bond weakening in seaborgium hexacarbonyl
Nature, Published online: 07 October 2026; doi:10.1038/s41586-026-11105-2Gas chromatography analysis of compounds formed by the superheavy element seaborgium shows that the hexacarbonyl complex Sg(CO)6 exhibits lower …
Chemistry Nobel awarded for solving mystery of how ‘handed’ organic molecules can …
Nature, Published online: 07 October 2026; doi:10.1038/d41586-026-03093-0Prize goes to two chemists who probed why life favours one mirror-image molecule over another.
How to control where semiconductor crystals start growing
Nature, Published online: 07 October 2026; doi:10.1038/d41586-026-02934-2Semiconductor crystals grow from tiny nuclei, but the position of these nuclei is difficult to control precisely and can …
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