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Interhemispheric monsoon dynamics over the past 450,000 years
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11166-3A 450 ka Andean speleothem record shows Southern and Northern Hemisphere monsoons generally vary out of phase, but occasionally …
Sexual dimorphism in epidermal stem cell dynamics
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11159-2Long-term live imaging of adult mouse ear skin reveals sex-specific differences in the clonal dynamics of epidermal stem cells …
Wave coarsening drives time crystallization in mechatronic metamaterials
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11163-6Wave coarsening in active elastic media is a phenomenon in which vibrations spontaneously increase in wavelength, period and amplitude …
Clasping folds enable superior elastic strength of graphene films
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11109-yTwo-dimensional graphene films with unusual folded surfaces are synthesized through a modular assembly strategy and show enhanced strength, toughness …
Hidden reaction pathways inform additive engineering for perovskite LEDs
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11120-3Resolution and control of the hidden solution-phase chemistry of 5-aminovaleric acid added to perovskite precursor solutions is described for …
Intrinsic physicochemical activity at microplastic–water interfaces
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11141-yCommodity microplastics exhibit intrinsic physicochemical activity at water interfaces, manifested by spontaneous generation of reactive oxygen species, challenging the …
Early tetrapod neck mobility modelled using an extant analogue
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11158-3Biomechanical analysis of several early tetrapods using sturgeon as an analogue revealed that early tetrapods had limited neck mobility …
Artificial intelligence-enabled clinical phenotyping of human brown fat
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11162-7Artificial intelligence-enabled quantification and analyses of brown adipose tissue (BAT) activity uncover links between BAT and a healthier metabolic …
Targeted stimulation of motor cortex ensembles drives learned movements
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11174-3Optogenetic stimulation of motor-cortex neuron ensembles shows that precisely timed activity in the primary motor cortex can generate learned …
Rh<sup>3+</sup> stabilized in KRh@MFI catalyses regioselective hydroformylation
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11136-9DFT investigations combined with spectroscopic and catalytic studies of disrupted subnanometric Rh2O3 clusters show that Rh+ centres in a …
Divergent genomic evolution in astrocytomas and oligodendrogliomas
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11150-xLongitudinal genomic analyses in patients with astrocytoma or oligodendrioglioma suggest that these two types of tumour differ in the …
Computational design of metalloproteases
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11167-2RFdiffusion methods are used to de novo design proteins with water-activating zinc-based active sites adjacent to a peptide substrate …
De novo design of cysteine proteases
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11143-wDe novo-designed enzymes use an activated cysteine nucleophile to hydrolyse polypeptide backbones in a sequence-dependent manner.
Evaluating space-based methane detection through a one-year blind test
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11115-0A year-long single-blind study shows that multiple satellites can accurately detect and quantify methane point-source emissions.
Capillary-selective vasodilation through myosin inhibition halts ischaemic cascades
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11171-6R(+)2501 reverses capillary no-reflow by relaxing pericytes, restoring microvascular perfusion and improving survival in animal models of myocardial infarction …
Parity-dependent coupling of molecular spin chains to a superconductor
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11117-yScanning tunnelling spectroscopy shows that the fractional spin-1/2 end states of molecular Haldane chains couple differently to a superconducting …
Competing mechanisms toughen bcc binary and medium-entropy alloys at 20 K
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11065-7The mechanical properties of medium-entropy alloys at 20 K show a plateau in tensile yield strength and fracture toughness …
Modelling mouse embryogenesis from chemically induced totipotent stem cells
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11164-5A mouse embryo model derived from chemically induced totipotent-like stem cells progresses through key developmental milestones, including gastrulation, embryonic …
<i>Elp1</i> is required for myeloid differentiation and brain repopulation
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11112-3Primary cultured haematopoietic stem and progenitor cells are used to analyse the molecular mechanisms of brain myeloid differentiation, and …
Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11176-1A tetravalent nanobody-based myeloid-selective IL-10 receptor agonist recapitulates IL-10’s potent suppression of monocytes, macrophages and dendritic cells while avoiding …
Global conservation area coverage substantially exceeds current estimates
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11157-4A globally representative sample of 25 countries and territories indicates that conservation areas cover 26.81% of the land, much …
Evidence for multi-Li<sup>+</sup> clustering in lithium-ion battery electrolytes
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11138-7Machine-learning-enabled atomistic simulations, spectroscopy, electrochemical data and quantum-chemical calculations reveal previously unstudied multi-lithium-ion complexes without bound anions, improving understanding …
Smartwatch health data are piling up. How can doctors keep pace?
Nature, Published online: 14 October 2026; doi:10.1038/d41586-026-03203-yTo harness the full value of wearable devices for monitoring and diagnosing medical conditions, protocols must be established.
Overlooked brown fat in our bodies linked to wide range of health …
Nature, Published online: 14 October 2026; doi:10.1038/d41586-026-03302-wMassive study of more than 100,000 people finds surprising connection between ‘good’ body fat and improved mental health.
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