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Prime assembly with linear DNA donors enables large genomic insertions
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10460-4Prime assembly can initiate Gibson-like assembly in cells to generate gene insertions without double-stranded DNA breaks, recombinases or homology-directed …
Charge-dependent spectral softenings of primary cosmic rays below the knee
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10472-0The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with …
Higher-order interactions enhance the latitudinal tree diversity gradient
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10434-6Higher-order interactions are shown to contribute to the decrease in species diversity from low to high latitudes in global …
Uncertain dynamic response of mid-latitude winter precipitation
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10474-ySeparating the anthropogenic forced thermodynamic and dynamic components from internal variability in winter precipitation trends in the mid-latitudes shows …
The past, present and future of de novo protein design
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10328-7A Review of de novo protein design highlights key methodological advances and achievements, current challenges and future applications.
GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10427-5GLP-1–GIP–lanifibranor, a single-molecule agonist of GLP-1R, GIPR, PPARα, PPARγ and PPARδ, shows promising therapeutic efficacy against obesity-linked metabolic dysfunction …
Increase in wild animal consumption across Central Africa
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10422-wWild meat is a fundamental component of the diets of rural Central African populations, accounting for 20% of the …
Spatial atlas of diabetic kidney disease reveals a B cell-rich subgroup
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10363-4A single-cell spatial atlas identifies a B cell-predominant microenvironment within the profibrotic tubular niche that marks a subset of …
Training language models to be warm can reduce accuracy and increase sycophancy
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10410-0Experiments on five different language models show that training language models to produce warmer responses can undermine the accuracy …
Cytoplasmic competition between separate parental pronuclei in zygotes
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10417-7Drug-based and manipulation-based strategies provide evidence of pronuclear competition for finite cytoplasmic resources between separate parental pronuclei in zygotes, …
Engineering tough blood clots for rapid haemostasis and enhanced regeneration
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10412-yEngineered blood clots using rapidly crosslinked red blood cells form within seconds, greatly improving toughness and adhesion while effectively …
Translation-dependent degradation of <i>cas12</i> mRNA triggered by an anti-CRISPR
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10440-8The anti-CRISPR protein AcrVA2 specifically interrupts Cas12a biogenesis by triggering co-translational mRNA degradation.
Vaccination generates broadly cross-neutralizing antibodies to the HIV Env apex
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10429-3A vaccination strategy using heterologous HIV Env trimers covalently coupled to liposomes for multivalent display generates cross-neutralizing HIV serum …
Transdimensional anomalous Hall effect in rhombohedral thin graphite
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10471-1The experimental observation of a fundamentally new type of anomalous Hall effect that couples both in-plane and out-of-plane orbital …
Improving access to essential medicines via decision-aware machine learning
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10433-7Nationwide deployment of a novel decision-aware machine learning framework as a decision support tool for the allocation of essential …
Digital quantum magnetism on a trapped-ion quantum computer
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10445-3Simulations performed using Quantinuum’s H2 trapped-ion quantum computer for observing thermalization on challenging timescales demonstrate the usefulness of digital …
Safety and efficacy of intratumoural anti-CTLA4 with intravenous anti-PD1
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10341-wThe phase 1b NIVIPIT trial shows that in combined therapy with intravenous nivolumab (anti-PD1), intratumoural administration of ipilimumab (anti-CTLA4) …
Recycling of spin-triplet excitons in organic photovoltaics
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10419-5Triplet excitons in OPVs can redissociate via the charge-transfer state into free carriers, reducing losses and improving efficiency, enabled …
Decarboxylative alkylation of alkenes
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10463-1A Pd-catalysed method enables regio- and diastereoselective C–H alkylation of diverse alkenes using carboxylic acids, expanding synthetic access to …
Immunity gets a boost from a surprising place — breakfast
Nature, Published online: 29 April 2026; doi:10.1038/d41586-026-01406-xEating a meal could lead to T cells springing into action more quickly— plus, 40 years after Chornobyl, how …
Reply to: Overestimating outsourced biodiversity loss may misguide policy
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10371-4Reply to: Overestimating outsourced biodiversity loss may misguide policy
Overestimating outsourced biodiversity loss may misguide policy
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10370-5Overestimating outsourced biodiversity loss may misguide policy
Author Correction: Broadly stable atmospheric CO<sub>2</sub> and CH<sub>4</sub> levels over the past …
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10600-wAuthor Correction: Broadly stable atmospheric CO2 and CH4 levels over the past 3 million years
America's special relationship 'probably Israel', says UK ambassador to US
The remarks, made in February and first reported by the Financial Times, came to light during the King's state visit.
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