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Why obesity drugs work better for some people: these genes hold clues
Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-01107-5Study of almost 28,000 people also identifies genetic variants that raise the risk of gastrointestinal side effects from GLP-1 …
Immolation
Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-01039-0Supply and demand.
Young tropical forests help to reverse biodiversity losses
Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-00811-6Forests that regrow on farmland are resilient and regain much of their lost biodiversity and species richness in 30 …
Brain organoids are a transformative technology — but they need regulation
Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-01021-wThe potential benefits of organoids for fundamental research and medicine are huge. Efforts to establish proper boundaries for their …
Genetics reveal why people respond differently to GLP-1 weight-loss drugs
Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-00905-1Genetic variants in GLP1R and GIPR, which encode targets of GLP-1-based medications, offer insights into why responses to these …
Hidden human–virus interactions uncovered in DNA in blood and saliva
Nature, Published online: 08 April 2026; doi:10.1038/d41586-026-01032-7The abundance of viral DNA was measured in DNA sequenced from blood and saliva samples in biobanks, revealing strong …
Synthetic super-enhancers enable precision viral immunotherapy
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10329-6Synthetic super-enhancers enable specific delivery of anticancer payloads, achieving tumour elimination after a single dose in a mouse model …
Superconductivity and electronic structures of nickelate thin film superstructures
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10352-7Engineered Ruddlesden–Popper nickelate superstructures show that specific Fermi surface features enable ambient-pressure superconductivity, linking structural configuration, electronic structure and …
Satellite imagery reveals increasing volatility in human night-time activity
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10260-wDaily satellite data reveal that Earth’s artificial lights at night are highly volatile, with frequent brightening and dimming between …
Population-scale repeat expansions elucidate disease risk and brain atrophy
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10345-6Decreased brain volumes and increased NfL levels can be observed earlier than disease diagnosis in short-tandem-repeat-associated neurological diseases.
Multiomics and deep learning dissect regulatory syntax in human development
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10326-9The Human Development Multiomic Atlas catalogues single-cell accessibility and gene expression data from human fetal cells across 12 organs, …
Metabolomics across scales: from single cells to population studies
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10277-1This Perspective reviews the potential and the challenges of metabolomics approaches, encompassing both single-cell and population-scale metabolomics.
Asymmetric selection of a rice immune module and rebuild of disease resistance
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10361-6Stacking XA48-mediated effector-triggered immunity with XA21-mediated pattern-triggered immunity in Oryza sativa japonica reconstitutes the broad-spectrum resistance from wild rice.
Clinical application of base editing for treating β-thalassaemia
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10342-9A clinical phase 1 trial of a single infusion of CS-101, CD34+ cells modified using a transformer base editor …
Mummified early Permian reptile reveals ancient amniote breathing apparatus
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10307-yA mummified fossil of the early Permian reptile Captorhinus reveals the potential ancestral amniote breathing mechanism and its impact …
Genetic predictors of GLP1 receptor agonist weight loss and side effects
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10330-zIdentification of genetic variants associated with the efficacy and side effects of GLP1 medications could underpin development of precision …
High-precision measurement of the W boson mass with the CMS experiment
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10168-5The CMS experiment at CERN reports one of the highest-precision measurements of the W boson mass, finding it in …
Single-cell spatiotemporal dissection of the human maternal–fetal interface
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10316-xA single-cell multiomic atlas of the human maternal–fetal interface across pregnancy reveals cell types, states and spatial niches, developmental …
High-fidelity collisional quantum gates with fermionic atoms
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10356-3A robust composite pair-exchange gate based on controlled interactions of fermionic atoms in an optical superlattice demonstrates high fidelities …
DNA damage drives antigen diversification in <i>Trypanosoma brucei</i>
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10337-6An in vitro toolkit for studying VSG diversification defines key molecular requirements underlying the formation of mosaic VSGs, providing …
The importance of competition and facilitation for global tree diversity
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10349-2Across 17 forest plots (2.7 million trees, 5,400 species), competition dominated overall, but facilitation was relatively stronger near the …
Saturation editing of <i>RNU4-2</i> reveals distinct dominant and recessive disorders
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10334-9Saturation genome editing of RNU4-2 identifies the functional and clinical impact of variants across the entire gene and delineates …
Author Correction: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10488-6Author Correction: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
Author Correction: Foundation model of neural activity predicts response to new stimulus …
Nature, Published online: 08 April 2026; doi:10.1038/s41586-026-10457-zAuthor Correction: Foundation model of neural activity predicts response to new stimulus types
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