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Exapted CRISPR–Cas12f homologues drive RNA-guided transcription
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10166-7Specialized σ factors interact with nuclease-dead, CRISPR–Cas12f proteins to form potent, RNA-guided gene activation systems that function independently of …
Homologous recombination deficiency and hemizygosity drive resistance in breast cancer
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10197-0Germline and somatic interactions define actionable genomic patterns driving acquired therapy resistance in breast cancer.
Structural basis of RNA-guided transcription by a dCas12f–σ<sup>E</sup>–RNAP complex
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10178-3Cryogenic electron microscopy reveals how dCas12f with σE recruits RNAP to targeted DNA, initiating transcription at a fixed downstream …
Wind shear enhances soil moisture influence on rapid thunderstorm growth
Nature, Published online: 04 March 2026; doi:10.1038/s41586-025-10045-7Analysis of millions of events over sub-Saharan Africa shows that wind shear amplifies the impact of soil moisture in …
Advancing operational global aerosol forecasting with machine learning
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10234-yReliable 5-day, 3-hourly forecasts of aerosol optical components and surface concentrations are obtained in 1 minute using a machine-learning-driven …
The molecular basis of force selectivity by PIEZO2
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10182-7PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in …
A glucocorticoid–FAS axis controls immune evasion during metastatic seeding
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10222-2Glucocorticoid receptor activation is a key driver of resistance of triple-negative breast cancer to both CD8+ T cells and …
Sea level much higher than assumed in most coastal hazard assessments
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10196-1Meta-analyses on a global scale show that the measured coastal mean sea level is higher than assumed in most …
Bulk hexagonal diamond
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10212-4The synthesis of millimetre-sized phase-pure hexagonal diamond, a polymorph of cubic diamond, by compressing highly oriented pyrolytic graphite under …
The oldest articulated bony fish from the early Silurian period
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10125-2A tiny, articulated, near-complete osteichthyan from the early Silurian Chongqing Lagerstätte, represents the oldest osteichthyan occurrence including microfossils, and …
Cell-free chromatin state tracing reveals disease origin and therapy responses
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10224-0cf-EpiTracing enables automated profiling of histone modifications in cell-free DNA from human plasma, allowing identification of the cells of …
Mechanism of co-transcriptional cap snatching by influenza polymerase
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10189-0Structural and biochemical studies of influenza virus RNA-dependent RNA polymerase (FluPol) in complex with transcribing host RNA polymerase II …
Microbiota-mediated induction of beige adipocytes in response to dietary cues
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10205-3In mice, a low-protein diet leads to a gut-microbiota-driven remodelling of adipose tissue towards brown fat, showing that gut …
Merlin: a computed tomography vision–language foundation model and dataset
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10181-8Merlin, a vision–language foundation model trained on a large dataset of paired CT scans, patient record data and radiology …
Lipid metabolism drives dietary effects on T cell ferroptosis and immunity
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10193-4The susceptibility of mouse and human T cells to ferroptosis is determined by the balance of systemic polyunsaturated and …
Long-term thrombus-free left atrial appendage occlusion via magnetofluids
Nature, Published online: 04 March 2026; doi:10.1038/s41586-025-10091-1In the presence of a sufficient magnetic field, magnetofluids can resist high-speed blood flow, offering a personalized and complete …
A metabolic alarmin from keratinocytes potentiates systemic humoral immunity
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10167-6Farnesyl pyrophosphate—a mevalonate pathway metabolic intermediate—is an endogenous alarmin that enhances IgG antibody responses through keratinocyte-derived IL-6 and CCL20.
Limited thermal tolerance in tropical insects and its genomic signature
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10155-wA survey of tropical insect populations and thermal tolerance limits indicates that species from lowland areas have low capacity …
DICER cleavage fidelity is governed by 5′-end binding pockets
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10211-5Cryo-electron microscopy and massively parallel assays shed light on the mechanism by which DICER, a key enzyme in the …
Genome modelling and design across all domains of life with Evo 2
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10176-5Evo 2 is an artificial intelligence-based biological foundation model trained on 9 trillion DNA base pairs spanning all domains …
Magnetic gel injected into the heart could stop strokes
Nature, Published online: 04 March 2026; doi:10.1038/d41586-026-00740-4The hydrogel-based plug blocks a part of the heart to cut stroke risk and was shown to be effective …
Heart surgery with quick-setting magnetic fluid could prevent strokes
Nature, Published online: 04 March 2026; doi:10.1038/d41586-026-00742-2Injectable fluid safely fills area in which blood clots can form, in animal trials — plus, strong evidence that …
Shared neural substrates of prosocial and parenting behaviours
Nature, Published online: 04 March 2026; doi:10.1038/s41586-026-10327-8Shared neural substrates of prosocial and parenting behaviours
Cancer blood tests are everywhere. Do they really work?
Nature, Published online: 04 March 2026; doi:10.1038/d41586-026-00661-2Their makers claim they can detect dozens of cancer types — but some scientists say they could be missing …
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