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The ‘missed disease’ that affects 190 million: endometriosis drug shows early promise
Nature, Published online: 01 October 2026; doi:10.1038/d41586-026-03042-xModified medication targets the cells implicated in the condition’s tell-tale lesions.
A two-hit mechanism triggers autoimmune hair loss
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11098-yImmune dysregulation and physiological neural activation converge to trigger autoimmune alopecia.
A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11093-3Proteomic and phosphoproteomic analyses of lysosomes identify a nutrient-independent regulatory arm of mTORC1 signalling that mediates lysosomal adaptation to …
Function-preserving watermarking of AI-generated proteins
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-10965-ySynthIDBio watermarks AI-generated protein sequences and structures while preserving function, enabling provenance detection and offering a proof-of-concept tool for …
Self-aligned optical microcomb emerging between octave-separated lasers
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11086-2An architectural inversion shifts integrated optical frequency comb generation from outward broadening around a central pump to filling the …
Butterfly wing patterns in flight create powerful illusory motion cues
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11062-wButterfly wing patterns and flight dynamics work in tandem to create powerful visual illusions that confuse predators, potentially representing …
Evolution of terrestrial anatomy revealed by a derived stem tetrapod
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11090-6New anatomical evidence reclassifies Westlothiana as an aquatic stem tetrapod, showing that terrestrial limb adaptations evolved mosaically in transitional …
Scalable decision-making for games of imperfect information
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11036-yAtaraxos, an AI for the board wargame Stratego, establishes a design pattern for reinforcement learning and search that is …
Spatiotemporal clonal architecture of the newborn mouse forebrain
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11064-8Clonal barcoding across the newborn mouse forebrain reveals developmental principles whereby glutamatergic neurons and astrocytes remain locally derived, whereas …
γδ T cell receptor dependencies define a unique immunosurveillance modality
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11076-4Tissue-resident γδ T cells mount rapid, innate-like stress responses that require γδ T cell receptor signalling, revealing lineage-specific receptor …
GPCR antagonism via rewiring of receptor trafficking and degradation
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11088-0A strategy for functional G-protein-coupled receptor (GPCR) antagonism through bispecific antibody-mediated endocytosis and lysosomal degradation is reported.
Transcription pause and elongation regulators mediate somatic hypermutation
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11092-4The molecular factors and mechanisms that mediate the chromatin recruitment of activation-induced deaminase and the generation of its stalled …
Written in development and lost in ageing: the grammar of cellular identity
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-10955-0Ageing reflects progressive decanalization of mammalian cell identity, driven by erosion of a regulatory grammar written during development.
Wafer-scale epitaxy growth of high-mobility p-type boron carbon nitride
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11047-9A dual-precursor chemical system is used to achieve wafer-scale epitaxy growth of boron carbon nitride, a high-performance p-type semiconductor, …
Prion-like transmission of human tau strains in the mouse brain
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11061-xMouse experiments show that Alzheimer’s disease and corticobasal degeneration tau filaments retain their distinct structures during templated seeding, supporting …
Human genetics implicates a BACH2–NRF2 axis in fetal haemoglobin activation
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11113-2BACH2 restrains activation of the fetal-haemoglobin-encoding γ-globin genes, while loss of BACH2 enhances NRF2 chromatin occupancy and promotes the …
Population-scale immune multiome atlas reveals regulatory disease mechanisms
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11078-2Population-scale simultaneous profiling of chromatin accessibility and gene expression across immune cells reveals regulatory architectures that connect genetic variants …
Osteoclasts intercept meningeal lymphatic paths for dural metastasis
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11082-6Osteoclast-derived angiopoietin-2 in the dura mater impairs lymphatic vessel function and weakens anti-tumour immunity against dural metastases, which offers …
Dynamic protrusions mediate crawling motility in Asgard archaea
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11063-9Anoxic live-cell imaging shows actin-dependent crawling motility and dynamic protrusions in Asgard archaea, providing insights into cellular innovations that …
An amygdala to anterior hypothalamic circuit gates stress sensitivity
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11075-5The anterior hypothalamic nucleus regulates negative valence in the brain, highlighting a new pathway that controls sensitivity to stressful …
Carbene transfer from thianthrenium ylides for cyclopropanation
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11108-zThianthrenium ylides can be used as a general platform for metal–carbene generation and transfer, including cyclopropanation, σ-bond insertion and …
Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11087-1By being restricted to target regions by MLLT1–MLLT3 occupancy, activation-induced deaminase activity is able to avoid most off-target mutagenesis …
X-ray liquidography decodes complex motions in azobenzene isomerization
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11068-4Time-resolved X-ray liquidography films the structural changes of azobenzene during trans-to-cis isomerization in solution with atomic-level precision.
Global mangrove distribution on the open coast is controlled by waves
Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11089-zA process-driven mangrove presence or absence model using 20 years of open-source wave data shows that wave conditions are …
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