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mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11054-wReactive astrocytes emerge as a primary consequence of TSC2 loss in tuberous sclerosis complex, implicating glial dysfunction as a …
Reference genomes and fossils revise bat family phylogeny and biogeography
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11007-3An updated phylogeny of bats is presented, based on new genome assemblies and many ancient fossils and including all …
A methanogen hydrolase reveals the structure of archaeal peptidoglycan
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11028-yArmA from Methanobrevibacter smithii, a dominant member of the human gut microbiome, is identified and characterized as a glycosyl …
A design approach for bitopic kinase inhibitors
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11056-8Detailed analyses of ligand choice, linkage vector and linker length enabled the development of bitopic inhibitors of ABL1 and …
Hepatocytes promote liver metastasis of pancreatic cancer by providing serine
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11051-zMetastatic pancreatic ductal adenocarcinoma (PDAC) in the liver that lack the enzyme necessary to synthesize serine can reprogram hepatocytes …
Banking records reveal characteristics of financial abuse
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11049-7An analysis of UK banking data reveals that people who reported being victim-survivors of financial abuse experience worse financial …
Sequence-encoded hexagonal lattices in multichannel peptide nanofibrils
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11016-2Nine-residue peptides can encode discrete interaction motifs that direct the formation of hexagonal pores, which hierarchically tile into laterally …
Lu<sup>+</sup> optical frequency references with accuracy verified at the 19th digit
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11072-8Two independent 176Lu+ single-ion optical clocks achieve fractional frequency uncertainties near 10−19 and agree at 5.7 × 10−19, advancing …
Single-nucleus transcriptome-wide association study of human brain disorders
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-10836-6Single-nucleus transcriptomics across diverse populations is used to explore how genetic risk for brain disorders affects specific cell types, …
Gravitational torque drives multidecadal variations in length of day
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-10999-2Multidecadal fluctuations in Earth’s length of day are shown to be driven by gravitational torque and resisted by electromagnetic …
The anthropogenic fingerprint on emerging infectious diseases
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11058-6Emerging infectious disease outbreak risks are ubiquitous worldwide, and highest in landscapes where people, livestock and fragmented natural ecosystems …
The gene-regulatory evolution of the human skeleton
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11053-xMassively parallel reporter assays and human–ape hybrid skeletal cells are used to study the evolution of human cis-regulatory elements …
Huge hoard of metal bars hints at vast Iron Age trade
Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02986-4One-tonne cache of iron is the largest ever found — and enough to make roughly 500 swords.
Competition heats up in the regenerative-medicine ranks
Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02856-zThe United States leads, but China poses strong competition, according to the latest Nature Index data.
Bank accounts reveal the fingerprints of abusive financial control
Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-03021-2Analysis of anonymized banking data could help inform strategies to support victim-survivors of financial abuse — plus, how opposing …
Chiral oxazolidinones <i>via</i> biocatalytic aziridination of unactivated alkenes
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11169-0Chiral oxazolidinones via biocatalytic aziridination of unactivated alkenes
Author Correction: Large recoverable elastic energy in chiral metamaterials via twist buckling
Nature, Published online: 23 September 2026; doi:10.1038/s41586-026-11189-wAuthor Correction: Large recoverable elastic energy in chiral metamaterials via twist buckling
How to stay smart in the age of AI: the science of …
Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02930-6There is growing concern that AI can blunt memory and reasoning. But science shows ways to keep the brain …
In praise of human teachers: universities must resist outsourcing everything to AI
Nature, Published online: 23 September 2026; doi:10.1038/d41586-026-02949-9An AI revolution is sweeping through education. But teachers who can convey the excitement of thinking and learning are …
Will AI really kill us all? The science behind the hype
Nature, Published online: 22 September 2026; doi:10.1038/d41586-026-02941-3Nature examines whether the technology might spell the end for humans, and why AI companies are calling for a …
Nepal floods pose biggest test yet for UN climate loss and damage …
Nature, Published online: 22 September 2026; doi:10.1038/d41586-026-03000-7Countries should not have to wait months to receive relatively small grants for responding to the immediate impact of …
All the ways a cell can die — and why the variety …
Nature, Published online: 22 September 2026; doi:10.1038/d41586-026-02929-zScientists are poking holes in established ideas about how cells live and die, and are harnessing these discoveries to …
This super-cold microscope could spur a quantum revolution
Nature, Published online: 22 September 2026; doi:10.1038/d41586-026-02942-2The instrument, which operates near absolute zero for hours, will soon ship to a few labs. Researchers are thrilled.
Dust in the wind is on the decline
Nature, Published online: 22 September 2026; doi:10.1038/d41586-026-02979-3The global decrease in atmospheric dust might be affecting Earth’s temperature.
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