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AI model predicts which breast-cancer drugs work best
Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02845-2Model trained on millions of protein measurements can gauge drug effectiveness in tissue samples taken from people with triple-negative …
In the basement of miniaturized relics
Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02416-5Thinking small.
Proximity-guided graph learning reveals tumour-associated proximity antigens
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11003-7A proximity-mapping atlas defines tumour-associated proximity antigens, revealing disease-associated membrane spatial communities, and identifies EGFR–CDCP1 as a co-target pair …
TM184C is a GPCR-like regulator of intercellular exchange and autophagy
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10993-8TM184C—an ancient G-protein-coupled receptor-like superdark protein involved in regulation of autophagy, intercellular connectivity and material exchange—underscores the promise of …
Integrated signatures define mutational processes in prostate cancer
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10468-wEight integrated mutational footprints collectively explain the mutational processes in 85% of primary prostate cancer genomes.
Anodic Pd membrane H<sub>2</sub> extraction enhances thermochemical dehydrogenation
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11008-2An electrochemical cell with molten hydroxide and a Pd membrane actively extracts H2 and thereby boosts ammonia and methylcyclohexane …
TRI-611, a selective, brain-penetrant molecular glue degrader of ALK
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10998-3TRI-611 induces the degradation of ALK fusion proteins via a previously undescribed CRBN recruitment motif, and its preclinical anti-tumour …
Imaging cellular activity across all organs reveals body-wide circuits
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10979-6An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and …
Predicting genome-wide functional constraints with GPN-Star
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11005-5GPN-Star, a genomic language model with a phylogeny-aware architecture for whole-genome alignment data, is shown to be a scalable …
Ancient proteins identify various Denisovan remains from Southwest China
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10976-9Identification and proteomic analysis of bone fragments and teeth from an excavation in Southwest China provide insight into the …
Mobile education builds resilience during shocks in five countries
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10990-xRemote phone-based targeted tutoring in five countries produced large, cost-effective learning gains during school closures, outperforming text messaging and …
A serpin–myeloid axis in pancreatic cancer heterogeneity and immune evasion
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11002-8SERPINE1 and SERPINB2-driven fibrin-rich niches locally programme immunosuppressive macrophages and exclude T cells, enabling spatially organized immune evasion in …
Denisovans from southwestern China and their subsistence strategies
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10997-4Evidence from Bianfu Cave shows specialized hunting, expedient stone-tool production and extensive bone use of Denisovans, providing new insights …
Advancing conflict research and response through satellite-derived data
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11004-6Integrating satellite-derived war-damage data with text-based fatality records through improvement, enrichment and fusion mitigates limitations inherent in each source, …
Ruins of ancient Asian city show engineering prowess and organization
Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02821-wThe 5,000-year-old city of Liangzhu has mounds, dams and city walls built in a challenging waterlogged site.
Foaming photopolymers as a high-resolution biomimetic printing platform
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10968-9Deep-foam photolithography uses light-controlled polymer foaming to create high-resolution, multifunctional microstructures with tunable optical, wetting and fluid-handling properties for …
PLA2G2D in tumour-draining lymph nodes regulates anti-tumour immunity
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10954-1A specific population of macrophages that express high levels of the enzyme PLA2G2D in tumour-draining lymph nodes is associated …
An operational perturbation proteomics-based virtual cell model
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11001-9Temporal protein-abundance measurements from systematically perturbed breast cancer cell lines were generated to develop ProteinTalks, a virtual cell model …
Neocortical long-range inhibition promotes cortical synchrony and sleep
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10876-yIn mice, a sparse population of sleep-active long-range inhibitory neurons in the neocortex promote widespread cortical synchronization and sleep, …
Phone tutoring boosts math scores when schools are forced to close
Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02843-4Evidence suggests that regular calls can keep kids learning when schooling is disrupted — plus, why a familiar world …
Within-family effect of ancestry on complex traits in a Mexican population
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11039-9This study uses a within-family design to identify significant ancestry differences in complex traits such as height and type …
Breaking timescales with generative sampling of conformational transitions
Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11025-1A generative committor-guided path-sampling framework reconstructs rare biomolecular transition pathways and reveals the underlying thermodynamics and kinetics without using …
Bacteria recruited to treat cancer
Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02823-8Anticancer drugs could be manufactured and delivered by modified microorganisms.
How AI is changing PhD programmes: join our free webinar
Nature, Published online: 09 September 2026; doi:10.1038/d41586-026-02751-7Learn how artificial intelligence can hone your research skills as well as the potential pitfalls of relying too heavily …
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