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Identification of broadly tumour-reactive γδ TCRs from multiple myeloma

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11055-9A machine-learning algorithm, PreGame, is developed to identify tumour-reactive γδ T cells from single-cell CITE sequencing data, and expansion …

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Assessing biological degradation of non-hydrolysable synthetic polymers

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-10918-5The evidence for biological degradation of non-hydrolysable synthetic polymers is critically evaluated to propose best-practice principles for experimental design …

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Cohesin reshapes replication fork contacts to aid fork slowing and reversal

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11034-0Cohesin-mediated loop extrusion limits sister-fork coupling and tethers nearby replication forks under replication stress, promoting fork reversal and slowing …

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Electrically controllable superconducting memory effect in UTe<sub>2</sub>

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11015-3Observations of a memory effect in the p-wave superconductor candidate UTe2, which can be controlled by varying the strength …

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Author Correction: Obesity rise plateaus in developed nations and accelerates in developing …

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11135-wAuthor Correction: Obesity rise plateaus in developed nations and accelerates in developing nations

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Scalable near-real-time Bayesian phylogenetics for outbreaks with Delphy

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11012-6Delphy makes near-real-time and scalable Bayesian phylogenetics possible for growing viral outbreaks, enabling public health bodies anywhere to analyse …

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Sex without crossovers mimics clonal reproduction in <i>Rhynchospora tenuis</i>

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11057-7Rhynchospora tenuis undergoes obligate, genome-wide achiasmy in both male and female meiosis.

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Targeted genomic integration and rearrangement using prime assembly

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11024-2Prime assembly enables RNA-guided integration of medium-to-large DNA sequences in human cells without requiring double-strand breaks or cell cycle …

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Molecular-level observation of the self-assembly of a virus-like particle

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-10948-zUsing mass photometry combined with a single-molecule trapping method allows real-time monitoring of the assembly of individual virus-like particles …

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Heterogeneous photonic integration of single-crystalline nanomembranes

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11000-wA framework consisting of advanced epitaxy and layer lift-off techniques uses heterogeneous photonic integration of single-crystalline nanomembranes to infuse …

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Rapid patient-specific neural networks for X-ray to volume registration

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11045-xxvr makes pan-anatomical 2D/3D rigid registration accessible to broad clinical and research communities.

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Transcriptional activation of plant immunity by salicylic acid

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11021-5A mechanistic basis for how the hormone salicylic acid promotes transcriptional activation during plant immune responses is described.

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Road transport of trapped antiprotons

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11019-zResearchers demonstrate successful road transport of trapped antiprotons, establishing a practical method for moving antimatter to quieter laboratories and …

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A retinoic acid autoregulatory loop governing prefrontal–motor arealization

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11014-4MEIS2, encoding a transcription factor linked to intellectual disability and autism spectrum disorder, is a key hub of a …

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Overmassive black holes and little red dots naturally form in simulations

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-10985-8Observations from the JWST reveal an unexpectedly abundant population of little red dots and overmassive black holes in the …

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Topographic structure and function of locus coeruleus noradrenaline neurons

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11026-0Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice …

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Evolution and heterogeneity of lethal metastatic bladder cancer subtypes

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11035-zA rapid autopsy programme provides valuable resources to enable detailed molecular and genetic analyses of the temporal evolution of …

Science Nature News
Mutational constraints on RSV F and its neutralization by antibodies

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11030-4How respiratory syncytial virus mutations affect antibody neutralization is defined, and a biophysical model of the mechanism is provided, …

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Continuous-wave laser absorption spectroscopy of the thorium-229 nucleus

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11011-7Absorption spectroscopy of thorium-229 nuclear excited states in a thorium-doped calcium fluoride crystal demonstrates a path towards a much …

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Electroluminescent photoresists extending lithographic scaling to OLEDs

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11042-0Electroluminescent photoresists synthesized via atom transfer radical polymerization can be directly patterned by ultraviolet and electron-beam lithography, and used …

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Reimagining research papers as interactive and reliable AI agents

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11044-yPaper2Agent converts research papers into interactive artificial intelligence agents by turning manuscripts, code and data into model context protocol-based …

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Mitochondrial fission factor senses and governs ferroptosis

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11020-6The mitochondrial–peroxisomal fission adaptor MFF is identified as a selective pro-ferroptotic mediator, and the newly developed MFF–SPARK sensor enables …

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Developmental xenocortication using human-derived organoids in mice

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11032-2Xenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice.

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Development of a random background to understand ligand optimization

Nature, Published online: 16 September 2026; doi:10.1038/s41586-026-11013-5An approach to improve efficiency and establish a background expectation for ligand potency optimization is described.

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