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Pervasive and programmed nucleosome distortion on single chromatin fibres
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10418-6An analytical pipeline called Iteratively Defined Lengths of Inaccessibility (IDLI) maps the genome-wide occupancy of a range of nucleosome …
Prime assembly with linear DNA donors enables large genomic insertions
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10460-4Prime assembly can initiate Gibson-like assembly in cells to generate gene insertions without double-stranded DNA breaks, recombinases or homology-directed …
Charge-dependent spectral softenings of primary cosmic rays below the knee
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10472-0The DAMPE satellite observed a universal charge-dependent spectral softening in primary cosmic rays, and ruled out mass-dependent softening with …
Higher-order interactions enhance the latitudinal tree diversity gradient
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10434-6Higher-order interactions are shown to contribute to the decrease in species diversity from low to high latitudes in global …
Uncertain dynamic response of mid-latitude winter precipitation
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10474-ySeparating the anthropogenic forced thermodynamic and dynamic components from internal variability in winter precipitation trends in the mid-latitudes shows …
The past, present and future of de novo protein design
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10328-7A Review of de novo protein design highlights key methodological advances and achievements, current challenges and future applications.
GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10427-5GLP-1–GIP–lanifibranor, a single-molecule agonist of GLP-1R, GIPR, PPARα, PPARγ and PPARδ, shows promising therapeutic efficacy against obesity-linked metabolic dysfunction …
Increase in wild animal consumption across Central Africa
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10422-wWild meat is a fundamental component of the diets of rural Central African populations, accounting for 20% of the …
Spatial atlas of diabetic kidney disease reveals a B cell-rich subgroup
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10363-4A single-cell spatial atlas identifies a B cell-predominant microenvironment within the profibrotic tubular niche that marks a subset of …
Training language models to be warm can reduce accuracy and increase sycophancy
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10410-0Experiments on five different language models show that training language models to produce warmer responses can undermine the accuracy …
Cytoplasmic competition between separate parental pronuclei in zygotes
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10417-7Drug-based and manipulation-based strategies provide evidence of pronuclear competition for finite cytoplasmic resources between separate parental pronuclei in zygotes, …
Engineering tough blood clots for rapid haemostasis and enhanced regeneration
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10412-yEngineered blood clots using rapidly crosslinked red blood cells form within seconds, greatly improving toughness and adhesion while effectively …
Translation-dependent degradation of <i>cas12</i> mRNA triggered by an anti-CRISPR
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10440-8The anti-CRISPR protein AcrVA2 specifically interrupts Cas12a biogenesis by triggering co-translational mRNA degradation.
Vaccination generates broadly cross-neutralizing antibodies to the HIV Env apex
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10429-3A vaccination strategy using heterologous HIV Env trimers covalently coupled to liposomes for multivalent display generates cross-neutralizing HIV serum …
Transdimensional anomalous Hall effect in rhombohedral thin graphite
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10471-1The experimental observation of a fundamentally new type of anomalous Hall effect that couples both in-plane and out-of-plane orbital …
Improving access to essential medicines via decision-aware machine learning
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10433-7Nationwide deployment of a novel decision-aware machine learning framework as a decision support tool for the allocation of essential …
Digital quantum magnetism on a trapped-ion quantum computer
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10445-3Simulations performed using Quantinuum’s H2 trapped-ion quantum computer for observing thermalization on challenging timescales demonstrate the usefulness of digital …
Safety and efficacy of intratumoural anti-CTLA4 with intravenous anti-PD1
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10341-wThe phase 1b NIVIPIT trial shows that in combined therapy with intravenous nivolumab (anti-PD1), intratumoural administration of ipilimumab (anti-CTLA4) …
Recycling of spin-triplet excitons in organic photovoltaics
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10419-5Triplet excitons in OPVs can redissociate via the charge-transfer state into free carriers, reducing losses and improving efficiency, enabled …
Decarboxylative alkylation of alkenes
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10463-1A Pd-catalysed method enables regio- and diastereoselective C–H alkylation of diverse alkenes using carboxylic acids, expanding synthetic access to …
Immunity gets a boost from a surprising place — breakfast
Nature, Published online: 29 April 2026; doi:10.1038/d41586-026-01406-xEating a meal could lead to T cells springing into action more quickly— plus, 40 years after Chornobyl, how …
Reply to: Overestimating outsourced biodiversity loss may misguide policy
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10371-4Reply to: Overestimating outsourced biodiversity loss may misguide policy
Overestimating outsourced biodiversity loss may misguide policy
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10370-5Overestimating outsourced biodiversity loss may misguide policy
Author Correction: Broadly stable atmospheric CO<sub>2</sub> and CH<sub>4</sub> levels over the past …
Nature, Published online: 29 April 2026; doi:10.1038/s41586-026-10600-wAuthor Correction: Broadly stable atmospheric CO2 and CH4 levels over the past 3 million years
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